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Professor Adil Mardinoglu (Principal Investigator)
Email: [email protected]; [email protected]

Professor Adil Mardinoglu is an expert in the field of Systems Medicine, Systems Biology, Computational Biology and Bioinformatics. He has been recruited as a Professor of Systems Biology in Center for Host-Microbiome Interactions, King’s College London, UK where he leads a computational group. He also works as group leader in Science for Life Laboratory (Scilifelab), KTH-Royal Institute of Technology in Sweden and led a team of 25 researchers working in the area of computational biology, experimental biology and drug development to develop new treatment strategies for Metabolic diseases, Neurodegenerative diseases and certain type of cancers.

Professor Mardinoglu received his Bachelor’s degree from Istanbul Technical University, Turkey in Electronic and Telecommunication Engineering and his Ph.D. from Waterford Institute of Technology, Ireland in magnetic drug targeting applications. He worked as a postdoctoral researcher at Trinity College Dublin, Ireland and Chalmers University of Technology, Gothenburg, Sweden. His recent research activities include the generation of the context specific genome-scale metabolic models (GEMs) for human cell-types including liver, adipose, muscle, heart, kidney and brain as well as certain types of cancer e.g liver, kidney, colon, prostate and brain (glioblastoma) cancers. His research team also focuses on the integration of GEMs with the other biological networks including regulatory, protein-protein interactions and signaling networks. He employs comprehensive biological networks for revealing the molecular mechanisms of complex diseases, identification of novel biomarkers and drug targets and eventually development of efficient treatment strategies.

Professor Mardinoglu has contributed to the creation of human tissue, subcellular and pathology atlas within the Swedish Human Protein Atlas program and cell atlas within the international Human Cell Atlas program. He has published around 100 research and review papers in different journals including Science, Cell Metabolism, Nature Communications, PNAS, Cell Reports, Molecular Systems Biology and EbioMedicine. He is also co-founder of three different biotech companies focusing on the development of novel drugs for fatty liver disease and different cancer types.


SENIOR RESEARCHERS


Dr. Cheng Zhang (Group Leader) @SciLifeLab
Email: [email protected]

Dr. Cheng Zhang received his B.Sc. degree in Bioengineering and Ph.D. degree in Fermentative Engineering at Department of Biotechnology, East China University of Science and Technology (ECUST). He also studied in Systems and Synthetic Biology group in Chalmers University as a visiting student for two years during his Ph.D. period.

Dr. Cheng Zhang is an experienced systems biologist, and he has conducted the creation of human pathology atlas and contributed to both human cell atlas project within the Swedish Human Protein Atlas program and the cell atlas within the international Human Cell Atlas program. So far, he has published more than 30 research and review papers in different journals including Science, Cell, Cell Metabolism, PNAS, Nucleic Acids Research, Molecular Systems Biology and Metabolic Engineering. His main research interests including developing and expanding genome-scale metabolic models to other omics level, and applying them into clinic such as investigating the driving factors, biomarkers or potential therapeutic strategies for obesity, non-alcoholic fatty liver disease and hepatocellular carcinoma. His research resulted in the development of a few novel drugs for fatty liver disease and different cancer types.


POSTDOCTORAL FELLOWS 


Dr. Woonghee Kim @SciLifeLab
Email: [email protected]

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Dr. Woonghee Kim received his Ph.D. degree in Chemical biology at Life Sciences Department, Gwangju Institute of Science and Technology, South Korea. He researched drug discovery and development that find new drugs to diseases, such as cancer, diabetes, myocardial infarction, and chemically induced stem cell therapy. He participated in a number of projects that developing anti-cancer new drug via glycolytic enzyme inhibition. Here, in Mardinoglu lab at SciLifeLab, Sweden, he is working on PKL targeting new molecules to cure hepatocellular carcinoma (HCC) and non-alcoholic steatohepatitis ( NASH).

 


Dr. Xiangyu Li @SciLifeLab
Email: [email protected]

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Dr. Xiangyu Li received her M.Sc. and Ph.D. in Bioinformatics from the Fujian Medical University, China. During her Ph.D. period, she focused on identifying metastasis and drug benefit predictive signatures at the individual level for caner patients and explored the genomic and epigenomic alternation of patients using the multi-omics data. She also developed a new algorithm of differential expression analysis for the small-scale cell line experiments. Currently, she is working on identifying classification signature for liver cancer based on metabolic difference.

 


Dr. Ozlem Altay @SciLifeLab
Email:
[email protected]

Ozlem Altay is a specialist in clinical microbiology, received her degree at Medical School of Hacettepe University, Turkey. As a post-doctoral researcher in our research group, her research interest is metatranscriptomic analyses of microbial communities in lung microbiota of cystic fibrosis patients.

 

 


Dr. Battisti Umberto Maria @University of Gothenburg
Email: [email protected]

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Dr. Battisti Umberto Maria received his B.M.Sc. in Chemistry and Pharmaceutical Sciences from the University of Modena and Reggio Emilia (Italy). His Ph. D. in Medicinal Chemistry was carried at the same university with several national and international PhD visiting fellowships. During his graduate studies, the main project was the development of new AMPA positive allosteric modulators. He worked as a postdoctoral researcher at University of Modena and Reggio Emilia (Italy), and Virginia Commonwealth University (USA). During the years he was involved in several areas, from CNS diseases to viral and parasitic  infections. His work as a medicinal chemist has already resulted in several publications, seminars and conference communications. His main research interests including drugs design employing classical medicinal chemistry approaches, the design of multi-steps synthetic strategies and stereoselective synthesis.


Dr. Chunxia Gao @University of Gothenburg
Email: [email protected]

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Dr. Chunxia Gao, a Chinese registered Pharmacist, recently completed her PhD degree in Chemistry from University of Gothenburg, Sweden. During her PhD studies, she was involved in several different projects and collaborated with various groups to develop anti-cancer inhibitors and antibiotics, which she applied computer-aided drug design approaches. Her work has already resulted in some potential inhibitors and publications. Chunxia will be a member of the research team working on designing small inhibitors that target enzymes involving in cell metabolism.

 


Dr. Leticia Monjas @University of Gothenburg
Email: [email protected]

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Dr. Leticia Monjas obtained her MSc degree in organic chemistry from the Complutense University of Madrid (Spain) and her PhD degree from the University of Groningen (The Netherlands). She has been involved in several medicinal chemistry projects. Her Master research focused on the synthesis and biological evaluation of multifunctional compounds for the treatment of Alzheimer’s disease. During her PhD she successfully applied different hit identification strategies, such as structure-based design, dynamic combinatorial chemistry and virtual screening, to develop small-molecule modulators of vitamin transporters in bacteria. Currently, she works on the development of kinase modulators for metabolic diseases.

 


Dr. Amalyn Nain @University of Gothenburg
Email: [email protected]

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Dr. Amalyn obtained her bachelor in Chemistry from the University of Los Andes (Venezuela), and her Master degree on synthesis of Agrochemicals from the Federal University of Viçosa (Brazil). She completed her PhD in Organic Chemistry at the Federal University of Minas Gerais (Brazil) working in projects that involved the synthesis of a large series of new analogues with high medicinal potential resulting in a fascinating structure-activity relationship. She is a highly motivated researcher and passionate for the organic synthesis with emphasis on the synthesis of natural products and analogues, organometallics, virtual screening and evaluation of biological activities

 


Dr. Josipa Matić @University of Gothenburg
Email: [email protected]

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Dr. Josipa Matić obtained her MSc degree in organic chemistry from the University of Zagreb (Croatia), and her PhD in medicinal chemistry from the University of Rijeka (Croatia). She gained most of her research experience while working at Ruđer Bošković Institute in Zagreb (Croatia). She has been involved in several projects related to medicinal chemistry field, including synthesis of nucleobase derivatives as potential antitumor agents, synthesis of peptide-based fluorescent probes, as well as spectroscopic studies of interactions of prepared compounds with biomolecules. As a postdoctoral researcher in this project, she is investigating potential kinase inhibitors for the treatment of metabolic disorders.

 


Dr. Anders Foller Füchtbauer @University of Gothenburg
Email: [email protected]

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Dr. Anders Foller Füchtbauer obtained his MSc and PhD degree in Pharmaceutical Chemistry from the University of Southern Denmark under Prof. Trond Ulven, where he designed, synthesized and developed a series of DNA ligands as anticancer agents, and investigated their pharmacodynamics and biological effects. He worked as a postdoctoral reasearcher at Chalmers University of Technology (Sweden) under Prof. Marcus Wilhelmsson, where he developed several novel fluorescent nucleic acid base analogues and evaluated them as probe molecules for DNA and RNA assays.
His work has so far resulted in 13 publications in in moderate to high impact chemistry journals. His main research interests includes drug design employing classical medicinal chemistry approaches, multi-step synthesis strategies, and heterocyclic chemistry. Currently, he works on the development of kinase modulators for metabolic diseases.

 


Dr. Alexandra Rodriguez Rivero @University of Gothenburg
Email: [email protected]

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Dr. Alexandra Rodriguez Rivero obtained her PhD degree in organic chemistry from the Complutense University of Madrid (Spain) where she worked on the development and study of new cyclisation processes mediated by transition metal complexes, under the supervision of Professor Israel Fernández López.
During her stay at the Pennsylvania University (USA), under the direction of Professor Patrick J. Walsh, she worked developing methods in palladium catalysed functionalization of unactivated C-H bonds.

After her PhD she joined the Carmen Carreño research group, at the University Autónoma of Madrid (Spain), to work in the synthesis of photo, electro and bioactive compounds.
Last year, she moved to Sweden to join the photoredox catalysis group of Professor Carl Johan Wallentin at the University of Gothenburg.
Recently, she joined us as postdoctoral fellow to work on the development of kinase modulators for metabolic diseases.

 


Dr. Shazia Iqbal @Istanbul Medipol University
Email:
[email protected]

JTKDr. Shazia Iqbal obtained her BS degree in chemistry from university of Karachi, Pakistan. She completed her Ph.D. on Organic Chemistry at HEJ Research institute of Chemistry (ICCBS), university of Karachi, Karachi, Pakistan in April 2019. She worked on two key projects in her M.phil leading to Ph.D., in one, she developed synthetic strategies and prepared analogues of medicinally important scaffolds via regioselective metal catalyzed click reaction and their biological activity evaluation. Second project (USA), she worked on the syntheses of structurally diverse electrophilic benzofused exo- and endocyclic acyl sultam scaffolds via reaction pairing CAP/CP strategies and in vitro reactivity profiling studies using both 19F- and 1H-NMR spectroscopy. During her Ph.D., she has discussed her work in various national, international conferences and ACS meetings and was awarded with first prize for her poster presentation, held during November 4-6, 2018, “2nd International Symposium on Natural Products for the Future (ISNPF-2)”. She was published her research work in international journals and some are in progress. She has got a wonderful experience during her PhD as a visiting research scholar at the University of Kansas, USA. Her areas of research include development of synthetic strategies to make small molecules as lead compounds, drug design and discovery, as well as medicinal chemistry. Recently, joined as postdoctoral fellow in GRG lab at the Istanbul Medipol University.

 


Dr. Munira Taj Muhammad @Istanbul Medipol University
Email:
[email protected]/a>

JTK
Dr. Munira Taj Muhammad has received her M.Sc. degree in Chemistry from University of Karachi (Pakistan). She obtained her doctorate in 2016 from H.E.J. Research Institute of Chemistry (ICCBS), University of Karachi, Karachi, Pakistan. She has a research experience of working as a postdoctoral fellow at Fujian institute of Research on the Structure of Matter (FJIRSM), Chinese Academy of Sciences, Fuzhou, Fujian, China. During her postdoctoral studies in china, she developed several novel methods of fluorination, amination and click reactions, while she has successfully completed three projects in that period. She has synthesized several drugable moeities and her PhD thesis comprises of several different projects all involving synthesis of drugs and drugable moeities. She has presented her work in various national and international conferences. Her basic research interests are Medicinal chemistry and the development of new methods of reactions via electroorganic and conventional routes. She has published more than 15 international publications in her short career so far. Currently Dr.Taj is involved in developing novel inhibitors for cancer with Prof. Dr. Mustafa Guzel at Medipol University Istanbul working as a postdoctoral fellow.

 


PHD STUDENTS


Muhammad Arif @SciLifeLab
Email: 
[email protected]
Personal Website: http://muharif.net

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Muhammad Arif received his B.Sc. degree from Bandung Institute of Technology, Indonesia and completed his master degree at KTH Royal Institute of Technology. His interests are in the development and implementation of machine learning and network analysis methods in biological context. His PhD project is focusing on the use of systems biology to understand the underlying mechanism of cardiovascular disease (CVD). As part of his education and works, he is involved in multiple projects including single-cell transcriptional analysis, biological network (co-expression and regulatory network), multi-omics integration, metabolic modelling and proteomics analysis.

 


Stephen Doran @King’s College London
Email:
[email protected]

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Stephen Doran completed his MChem degree in chemistry at the University of Manchester and then obtained his MSc degree in bioinformatics and systems biology from the same university. He has been involved in several research projects, which include investigating alcoholic selection in yeast using genomics software tools and CNV interpretation using novel bioinformatics tools for patients with developmental disorders. Stephen has also previously implemented and numerically analysed an existing dynamical model of STAT transcription factor signalling in order to gain a more detailed understanding of cellular immune responses. In the Mardinoglu lab, he will be using a systems biology approach for whole body modelling of patients with cardiovascular disease.

 


Simon Lam @King’s College London
Email:
[email protected]

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Simon Lam graduated from Gonville & Caius College, University of Cambridge with BA and MSc degrees in Natural Sciences (Biochemistry). He gained his research experience in bioinformatics while at the University of Birmingham, University of Cambridge, and Microsoft Research, Cambridge. His research contributions include developing predictive models to study modular interactions of trans-acyltransferase polyketide synthases, as well as generating an executable network to describe and predict whole-cell signalling in non-small-cell lung cancer in mice. Simon’s research interests primarily include computational biology, big data in biology, and cancer biology. As a member of the Mardinoglu lab, he is using multi-omics approaches to construct molecular networks of human brain tissue.

 


VISITING SCIENTISTS


Mohamed Al Shobky @SciLifeLab
Email: 
[email protected]

mohamed.newMohamed Al Shobky is an Egyptian-registered Clinical Pharmacist received his B.Sc. degree in Clinical Pharmaceutical Science, Zagazig University, Egypt. Currently, he is an M.Sc. student of tumour biology programme with a major in Systems Biology at Skövde University. Within our research group, he is pursuing his master thesis working on the identification of novel anticancer drug targets utilising various systems biology approaches, under the Supervision of Dr. Adil Mardinoglu and Dr. Sunjae Lee.

 


Shuqi Chen @SciLifeLab
Email: 
[email protected]

Shuqi Chen received her B.Sc.degree in biotechnology from Agricultural University of Hebei, China, and her master degree in conservation biology at Lund University, Sweden. With her comprehensive background, she is also skilled in RNA-Seq, metagenomics, and meta-transcriptomics data analysis. Her research interest is to understand diseases such as type 2 diabetes and obesity using systems biology approaches.

 

 


Mehmet Ozcan @SciLifeLab
Email:
[email protected]

JTKMehmet Ozcan received his B.Sc degree in Chemistry from Cukurova University and his M.Sc. degree in Medical Biochemistry from Hacettepe University, Turkey. Currently, he is a Ph.D. student at Hacettepe University in the same area. His research interest is antioxidant system and drug resistance in cancer treatment.

 

 


Elyas Mohammadi @SciLifeLab
Email:
[email protected]

Elyas Mohammadi received his M.Sc. degree from Ferdowsi University of Mashhad, Iran. His interests are in wet lab and computational biology (including structural bioinformatics and immunoinformatic) regarding therapeutic peptides and vaccine development. Recently, he has started working on Omics data integration and drug repurposing through system biology approaches in Sysmedicine group.

 

 



FORMER LAB MEMBERS

  • Feride Eren, Lund Univertsity
  • Jung Tae Kim
  • Kajetan Juszczak
  • Rui Benfeitas, National Bioinformatic Infrastructure of Sweden (NBIS)
  • Alen Lovric, Karolinska University Hospital
  • Beste Turanli, Marmara University
  • Natasa Sikanic, Karolinska University Hospital
  • Dorines Rosario, Kings College London
  • Nadia Karimpour, Kings College London
  • Dr. Gholamreza Bidkhori, Kings College London
  • Dr. Sunjae Lee, Kings College London
  • Dr. Zhengtao Liu, Zhejiang University
  • Dr. Fady Akladios, Charles Sturt University, Australia
  • Ida Larsson, Uppsala University
  • Sumit Deshmukh, University of Skövde
  • Dr. Kemal Sanli, University of Gothenburg
  • Ezgi Elmas, Mugla Sitki Kocman University, Turkey
  • Azadeh  Mohammad Pour, King’s College London
  • Baris Sadik, Bogazici University, Turkey
  • Christofer Boren, KTH – Royal Institute of Technology
  • Tim Kuijpers, Eindhoven University of Technology, Netherlands
  • Pisanu Buphamalai, KTH – Royal Institute of Technology
  • Dr. Bunjamin Memishi, Universidad Politecnica de Madrid

Group Photo

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