Why Systems Biology?
Systems biology is an interdisciplinary subject where the systems of biological components are studied using mathematical models, computational models and experimental technologies such as genomics, proteomics, transcriptomics and metabolomics. It includes application and development of systems biological methods with particular emphasis on integration, analysis and modelling of big data within the field of molecular biosciences.
Mardinoglu lab at SciLifeLab develop Genome-scale metabolic models (GEMs) for human cells/tissues and employ these comprehensive models in the analysis of the omics data obtained from subjects with complex diseases including obesity, Non-alcoholic fatty liver disease (NAFLD), Type 2 diabetes (T2D) and certain types of cancer (e.g. Hepatocellular Carcinoma) This is an exciting area of biomedical research, driven by the increase of common metabolic disorders as well as recent discoveries of metabolic reprogramming in cancer.